1 answer

Please show how you would synthesize a terminal ALKYNE to this fluorescein dye. Terminal alkyne s...

Question:

Please show how you would synthesize a terminal ALKYNE to this fluorescein dye.

Terminal alkyne should be added to the bottom aromatic (with the COOH group)

you can use any reagent possible

COOH

COOH

Answers

We can add terminal alkyne through Friedel-Craft alkylation/acylation as shown below:

HO COOH Fa Br 3 HO COOH CHCNHCH.CCH

.

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