## Answers

**3**.

Step 1:

Conversion of alkene to alcohol using hydroboration-oxidation reaction.

Step 2:

TMS (trimethylsilyl) protection of the alcohol functional group so that it does not react with the Grignard reagent formed in next step.

Step 3:

Preparation of Grignard reagent.

Step 4:

Formation of carboxylic acid from the reaction of Grignard reagent with carbon dioxide.

Step 5:

TMS deprotection using TBAF (tetrabutylammonium fluoride) regenerates the alcohol functional group.

Step 6:

Heating facilitates the formation of the cyclic ester or lactone which is the target molecule.

1. ВНз. ТHF TMSCI, NEt3 TMSO НО. Br Br Br 2.

.
H20, H202, NaOH Mg TMSO MgBr 1. CO2 2. НО" ТВАF TMSO НО СООН СООН

#### Similar Solved Questions

1 answer

##### How do you use the definition of a derivative to find the derivative of #f(x)=x^3+5x^2+6#?

How do you use the definition of a derivative to find the derivative of #f(x)=x^3+5x^2+6#?...

1 answer

##### Exercise 12-2 During December of the current year, Teletex Systems, Inc., a company based in Seattle,...

Exercise 12-2 During December of the current year, Teletex Systems, Inc., a company based in Seattle, Washington, entered into the following transactions: Dec. 10 Sold seven office computers to a company located in Colombia for 9,036,000 pesos. On this date, the spot rate was 360 pesos per U.S....

1 answer

##### A piston/cylinder with a cross- sectional area of .01 m^2 has a piston mass of 100...

A piston/cylinder with a cross- sectional area of .01 m^2 has a piston mass of 100 kg resting on stops. With an outside atmospheric pressure of 120 kPa , what should the water pressure be to lift the piston?...

1 answer

##### I know the right answer is -233.8 but can someone please show the steps to get...

I know the right answer is -233.8 but can someone please show the steps to get there? Thanks! Question4 10 10 pts The value of [delta)Ho for: 2 H2S (g) +SO2 (g) 3 S (s) + 2 H20 () is: H2 (g) 1/2 02 (g)H2O) [deltajH°-285.8 kJ H2 (g)S (s) > H2S (g) [delta)H°-20.5 kJ S (s) +O2 (8) >SO2 (g...

1 answer

##### Help please A buffer solution contains 0.382 M NaH2PO4 and 0.434 M K HPO4 If 0.0161...

help please A buffer solution contains 0.382 M NaH2PO4 and 0.434 M K HPO4 If 0.0161 moles of hydrobromic acid are added to 125 mL of this buffer, what is the pH of the resulting solution? (Assume that the volume does not change upon adding hydrobromic acid) pH = Submit Answer Retry Entire Group ...

1 answer

##### 1. The 12-ft beam is initially at rest when the 1-ft diameter drums are given angular...

1. The 12-ft beam is initially at rest when the 1-ft diameter drums are given angular accelerations of a1 = 0.3 rad/sand az = 0.5 rad/s2 in the directions shown. 1 ft o 1 ft ali 02 4 ft 4 ft 4 ft a. Determine the acceleration vectors of points A and B on the beam С A B b. Calculate the angular...

1 answer

##### Observation of a streak-plate culture show more growth in quadrant #4 than in quadrant #3. What...

Observation of a streak-plate culture show more growth in quadrant #4 than in quadrant #3. What could account for this observation? loop was properly sterilized after every single streak ОА. student got distracted and as they were streaking quadrant 14, they crossed through quadrant OB s...

1 answer

##### Class Management Help Assignment 7 Begin Date: 4/21/2018 12:00:00 AM-Due Date: 5/9/2018 11:59:00 PM End Date:...

Class Management Help Assignment 7 Begin Date: 4/21/2018 12:00:00 AM-Due Date: 5/9/2018 11:59:00 PM End Date: 5 112018 11:59:00 PM (4% Problem 13: A student is getting her picture taken by a digital camera. The student is 1.55 m tall and she stands do 3.75 m in front of the camera lens which has a f...

1 answer

##### Kerch Co. had beginning net fixed assets of $216,558, ending net fixed assets of $211,722, and...

Kerch Co. had beginning net fixed assets of $216,558, ending net fixed assets of $211,722, and depreciation of $40,471. During the year, the company sold fixed assets with a book value of $8,038. How much did the company purchase in new fixed assets? Multiple Choice $43,673 $41,510 $35,635 $32,433 $...

1 answer

##### Please use ths calculous 2 class information help me with this . 4) Fifty meters of...

please use ths calculous 2 class information help me with this . 4) Fifty meters of a circular observation tube with a flat glass window at the bottom is submerged in water as shown. Assuming P(h) = 9800 h / m2, calculate the total force due to hydrostatic pressure (30pts.) on the exterior of t...

1 answer

##### Exercise 16-06 On February 1, Cullumber Company purchased 280 shares (2% ownership) of Givens Company common...

Exercise 16-06 On February 1, Cullumber Company purchased 280 shares (2% ownership) of Givens Company common stock for $32 per share. On March 20, Cullumber Company sold 56 shares of Givens stock for $1,624. Cullumber received a dividend of $3.00 per share on April 25. On June 15, Cullumber sold 112...

1 answer

##### Evaluate the determinant, in which the entries are functions. Determinants of this type occur when changes...

Evaluate the determinant, in which the entries are functions. Determinants of this type occur when changes of variables are made in calculus. 5x 6 In x 56/ Evaluate the determinants to determine whether the equation is true or false. w x Ty z w x Evaluate the determinants. I w x V *N NX LY Z- Twx Is...

1 answer

##### Introduction For over a century Northwestern Hospital's use of EBM has enabled clinicians and practitioners to...

Introduction For over a century Northwestern Hospital's use of EBM has enabled clinicians and practitioners to incorporate best treatment practices at the point of patient care in both their hospital and ambulatory organizations. For example, Northwestern's goal to enhance quality delivery a...

1 answer

##### A random sample of 64 observations produced a mean value of 84 and standard deviation of...

a random sample of 64 observations produced a mean value of 84 and standard deviation of 4.5 the 95% confidence interval for the population mean u is between a. 80.898 and 87.103 b. 82.398 and 85.603 c. 83.075 and 84.925 d. 82.898 and 85.103 e. 83.398 and 84.603...

1 answer

##### Swifty Company sells 8% bonds having a maturity value of $3,000,000 for $2,772,550. The bonds are...

Swifty Company sells 8% bonds having a maturity value of $3,000,000 for $2,772,550. The bonds are dated January 1, 2020, and mature January 1, 2025. Interest is payable annually on January 1. Determine the effective-interest rate. The effective-interest rate...