# 21. Answer ALL parts of this question. The anti-inflammatory agent, (S)-naproxen sodium salt has a specific...

###### Question:

21. Answer ALL parts of this question. The anti-inflammatory agent, (S)-naproxen sodium salt has a specific rotation of +66º. The commercial preparation of the latter agent results in a mixture that has a 97% enantiomeric excess (ee). colo H3C0 (S)-naproxen sodium salt (a) Draw the R enantiomer of naproxen sodium salt. (1 mark) (b) What effect does the R enantiomer have on plane-polarized light? (1 mark) (c) What is the observed specific rotation of anti-inflammatory agent mixture? (4 marks) (d) What percentage of each enantiomer is obtained from the above commercial mixture? (2 marks) (e) Provide a reaction scheme for the formation of the (S)-naproxen sodium salt from “acidic" (S)-naproxen. (2 marks)

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