Why do tamoxifen and herceptin not work against basal-like breast cancer?

2 answers
Question:

Why do tamoxifen and herceptin not work against basal-like breast cancer?

Answers

 This is because basal-like breast cancers, do not express estrogen receptor (ER) or progesterone receptor (PR) and lacks human epidermal growth factor receptor 2 (HER2) overexpression or amplification. Due to the absence of molecular targets, they are unlikely to respond to medications such as tamoxifen and Herceptin that target the aforementioned receptors.

Due to the absence of HER2 (human epidermal growth factor receptor 2) protein, the tamoxifen and Herceptin do not work against the basal-like breast cancer. Further Explanation: The breast cancer occurs in the cells of the breast. They begin to divide abnormally. The cells start dividing unconditionally as compared to normal cells. They form lump or mass of cells that can metastasize to the lymph node and other regions of the body. The unconditional division of the cells begins with the cell of the milk-producing duct. It can also begin from glandular tissue (lobules). This cancer is also associated with mutated gene inherited from either of the parent. Human epidermal growth factor receptor 2 (HER2) genes have a crucial role in breast cancer development. It is present on the surface of the cancer cells that helps in receiving signals for growth and metastasizes. Basal-like breast cancer lacks this protein due to which it cannot be treated with tamoxifen and Herceptin. The tamoxifen and Herceptin are the medicines used for cancer therapy or targeted therapy. HER2 positive cancers are really hard to treat. Learn More: 1. Learn more about the treatment of eukaryotic cell with a drug https://brainly.com/question/10767798 2. Learn more about the proteins synthesis in a cell https://brainly.com/question/1420458 3. Learn more about exchange of gases by blood cells https://brainly.com/question/1213217 Answer Details: Grade: High School Subjects: Biology Topic: Cancer Keywords: Breast, cancer, cell, abnormally, lump, mass, metastasize, epidermal, growth, mutated, inherited, basal, herceptin, tamoxifen, growth.

Similar Solved Questions

1 answer

For f(x) = 2x + 1 and g(x) = x2 – 7, find (f + g)(x). A. x2 + 2x – 6 B. 2x3 – 6 C. x2 + 2x + 8 D. 2x2 – 15

For f(x) = 2x + 1 and g(x) = x2 – 7, find (f + g)(x). A. x2 + 2x – 6 B. 2x3 – 6 C. x2 + 2x + 8 D. 2x2 – 15...
1 answer

What is 5/8+5/6 this is hard

What is 5/8+5/6 this is hard...
2 answers

Which of the following situations would not viot the Americans with disabilities act

which of the following situations would not viot the Americans with disabilities act...
1 answer

Some scientists propose that before modern cells arose , RNA dominated the world. Which statement below , if true, would provide evidence for this hypothesis?

Some scientists propose that before modern cells arose , RNA dominated the world. Which statement below , if true, would provide evidence for this hypothesis?...
1 answer

A teacher makes a request of a student. The student emits aggressive behavior immediately following the request. The teacher removes the request in order to avoid getting hit. The teacher's request:

A teacher makes a request of a student. The student emits aggressive behavior immediately following the request. The teacher removes the request in order to avoid getting hit. The teacher's request:...
1 answer

If y = 9x − 7, which of the following sets represents possible inputs and outputs of the function, represented as ordered pairs?

If y = 9x − 7, which of the following sets represents possible inputs and outputs of the function, represented as ordered pairs?...
1 answer

What was the British reaction to the increased Jewish immigration before WWII? Explain what it did.

what was the British reaction to the increased Jewish immigration before WWII? Explain what it did....
2 answers

Please help please i really need it

please help please i really need it...
1 answer

Ima cry brainliest giving it out Stefanie has 18 grams of 20% sugar syrup and john 30 of 25% if Stefanie and john mix the syrups together how many grams of sugar will they have?

ima cry brainliest giving it out Stefanie has 18 grams of 20% sugar syrup and john 30 of 25% if Stefanie and john mix the syrups together how many grams of sugar will they have?...
1 answer

Need help with this emt assignment so hard

Need help with this emt assignment so hard...
1 answer

Using the expression 3x + 5, How many terms are there?​

Using the expression 3x + 5, How many terms are there?​...
1 answer

What did Native American groups use as a way to improve hunting or to clear land for Certain plants to grow

What did Native American groups use as a way to improve hunting or to clear land for Certain plants to grow...
1 answer

What type of plant community will develop at an average annual temperature of 15 C and an average annual precipitation of 150 cm

what type of plant community will develop at an average annual temperature of 15 C and an average annual precipitation of 150 cm...
1 answer

What reason(s) does Thurmond give for opposing the first proposal? ​

What reason(s) does Thurmond give for opposing the first proposal? ​...
1 answer

SOMEONE HELP ME PLEASE

SOMEONE HELP ME PLEASE...
2 answers

Which shows the fraction rewritten with their LCD? 3/8 and 1/4 A. 6/16 and 12/16 B. 3/8 and 4/8 C. 3/8 and 2/8 D. 6/16 and 4/16 The Answer will be A, I just took the Quiz!! :)

Which shows the fraction rewritten with their LCD? 3/8 and 1/4 A. 6/16 and 12/16 B. 3/8 and 4/8 C. 3/8 and 2/8 D. 6/16 and 4/16 The Answer will be A, I just took the Quiz!! :)...
1 answer

PLEASE ANSWER ASAP FOR BRANLEST!!!!!!!!!!!!!!! Solve this equation and show your work step by step using PEMDAS 3y + 6 = 30

PLEASE ANSWER ASAP FOR BRANLEST!!!!!!!!!!!!!!! Solve this equation and show your work step by step using PEMDAS 3y + 6 = 30...
2 answers

If in ∆ABC , ∠C = 90° , CD⏊AB, CD = h, BC = a, CA = b and AB = c, prove that 1/h² = 1/a² + 1/b².​

If in ∆ABC , ∠C = 90° , CD⏊AB, CD = h, BC = a, CA = b and AB = c, prove that 1/h² = 1/a² + 1/b².​...
2 answers

The debate of free will vs. Determinism has extended back for many centuries.True or false

The debate of free will vs. Determinism has extended back for many centuries.True or false...
1 answer

Explain the equasion how to get the answer to how 1/3 of a carton of eggs equals 4

Explain the equasion how to get the answer to how 1/3 of a carton of eggs equals 4...

-- 0.013329--